Function and Biology

Structure of the DNA binding domains of NFAT and FOXP2 bound specifically to DNA.

Source organism: Homo sapiens
Biochemical function: DNA-binding transcription factor activity
Biological process: regulation of transcription, DNA-templated
Cellular component: not assigned

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00554
Domain description: Rel homology DNA-binding domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
1 copy of Pfam domain PF00554 (Rel homology DNA-binding domain) in Nuclear factor of activated T-cells, cytoplasmic 2 in PDB 2as5.

PF00250
Domain description: Forkhead domain
Occurring in:
  1. Forkhead box protein P2
1 copy of Pfam domain PF00250 (Forkhead domain) in Forkhead box protein P2 in PDB 2as5.

InterPro InterPro annotations
IPR001766
Domain description: Fork head domain
Occurring in:
  1. Forkhead box protein P2
IPR008366
Domain description: Nuclear factor of activated T cells (NFAT)
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR008967
Domain description: p53-like transcription factor, DNA-binding
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR037059
Domain description: Rel homology domain (RHD), DNA-binding domain superfamily
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. Forkhead box protein P2
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Forkhead box protein P2
IPR032397
Domain description: Rel homology dimerisation domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR011539
Domain description: Rel homology domain (RHD), DNA-binding domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
IPR002909
Domain description: IPT domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Nuclear factor of activated T-cells, cytoplasmic 2 in PDB 2as5.
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Forkhead box protein P2
1 copy of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Forkhead box protein P2 in PDB 2as5.
2.60.40.340
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Rel homology domain (RHD), DNA-binding domain
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
1 copy of CATH domain 2.60.40.340 (Immunoglobulin-like) in Nuclear factor of activated T-cells, cytoplasmic 2 in PDB 2as5.
SCOP SCOP annotations
81279
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: E set domains
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
1 copy of SCOP domain 81279 (NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain) in Nuclear factor of activated T-cells, cytoplasmic 2 in PDB 2as5.
81315
Class: All beta proteins
Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f
Superfamily: p53-like transcription factors
Occurring in:
  1. Nuclear factor of activated T-cells, cytoplasmic 2
1 copy of SCOP domain 81315 (Rel/Dorsal transcription factors, DNA-binding domain) in Nuclear factor of activated T-cells, cytoplasmic 2 in PDB 2as5.
46832
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Occurring in:
  1. Forkhead box protein P2
1 copy of SCOP domain 46832 (Forkhead DNA-binding domain) in Forkhead box protein P2 in PDB 2as5.