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Crystal structure of a dimeric caspase-9

X-ray diffraction
2.8Å resolution
PDB entry 2ar9 coloured by chain, front view.
PDB entry 2ar9 coloured by chain, side view.
PDB entry 2ar9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Caspase-9 subunit p35
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Multimeric state: homo dimer
Accessible surface area: 18909.36 Å2
Buried surface area: 3454.46 Å2
Dissociation area: 1,625.99 Å2
Dissociation energy (ΔGdiss): 16.42 kcal/mol
Dissociation entropy (TΔSdiss): 13.1 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-157266
Assembly 2
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Assembly Name: Caspase-9 subunit p35
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Multimeric state: homo dimer
Accessible surface area: 19203.72 Å2
Buried surface area: 3212.3 Å2
Dissociation area: 1,606.15 Å2
Dissociation energy (ΔGdiss): 14.43 kcal/mol
Dissociation entropy (TΔSdiss): 13.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-157266

Macromolecules

Caspase-9 subunit p35
Chains: A, B, C, D
Length: 278 amino acids
Theoretical weight: 30.55 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P55211 (Residues: 139-416; Coverage: 67%)
Gene names: CASP9, MCH6
Pfam: Caspase domain
InterPro:
CATH: Rossmann fold
Caspase-9 subunit p35 in PDB entry 2ar9, assembly 1, front view.
Caspase-9 subunit p35 in PDB entry 2ar9, assembly 1, side view.
Caspase-9 subunit p35 in PDB entry 2ar9, assembly 1, top view.
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