X-ray diffraction
2.1Å resolution

Crystal structure of human PGRP-IalphaC in complex with muramyl pentapeptide


Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidoglycan recognition protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 165 amino acids
Theoretical weight: 18.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q96LB9 (Residues: 177-341; Coverage: 51%)
Gene names: PGLYRP3, PGRPIA
Structure domains: Peptidoglycan recognition protein-like
muramyl pentapeptide Chains: C, D
Molecule details ›
Chains: C, D
Length: 7 amino acids
Theoretical weight: 762 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P21
Unit cell:
a: 37.86Å b: 58.63Å c: 70.4Å
α: 90° β: 93.65° γ: 90°
R R work R free
0.231 0.227 0.267
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided