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Histamine Methyltransferase (Natural Variant I105) Complexed with the Acetylcholinesterase Inhibitor and Altzheimer's Disease Drug Tacrine

X-ray diffraction
2.97Å resolution
PDB entry 2aow coloured by chain, front view.
PDB entry 2aow coloured by chain, side view.
PDB entry 2aow coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histamine N-methyltransferase
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Multimeric state: monomeric
Accessible surface area: 13131.66 Å2
Buried surface area: 557.0 Å2
Dissociation area: 278.5 Å2
Dissociation energy (ΔGdiss): -4 kcal/mol
Dissociation entropy (TΔSdiss): 2.96 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156132
Assembly 2
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Assembly Name: Histamine N-methyltransferase
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Multimeric state: monomeric
Accessible surface area: 13135.35 Å2
Buried surface area: 555.45 Å2
Dissociation area: 277.72 Å2
Dissociation energy (ΔGdiss): -5.44 kcal/mol
Dissociation entropy (TΔSdiss): 2.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156132

Macromolecules

Histamine N-methyltransferase
Chains: A, B
Length: 292 amino acids
Theoretical weight: 33.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50135 (Residues: 1-292; Coverage: 100%)
Gene name: HNMT
Pfam: Methyltransferase domain
InterPro:
CATH: Vaccinia Virus protein VP39
SCOP: Histamine methyltransferase
Histamine N-methyltransferase in PDB entry 2aow, assembly 1, front view.
Histamine N-methyltransferase in PDB entry 2aow, assembly 1, side view.
Histamine N-methyltransferase in PDB entry 2aow, assembly 1, top view.
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