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Protein-peptide complex

Source organism: Mus musculus
Biochemical function: zinc ion binding
Biological process: multicellular organism development
Cellular component: cytoplasm

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EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Sequence families

Pfam Protein families (Pfam)
PF03145
Domain description: Sina, TRAF-like domain
Occurring in:
  1. E3 ubiquitin-protein ligase SIAH1A
The deposited structure of PDB entry 2an6 contains 4 copies of Pfam domain PF03145 (Sina, TRAF-like domain) in E3 ubiquitin-protein ligase SIAH1A. Showing 1 copy in chain A.

PF21361
Domain description: Sina, zinc finger
Occurring in:
  1. E3 ubiquitin-protein ligase SIAH1A
The deposited structure of PDB entry 2an6 contains 4 copies of Pfam domain PF21361 (Sina, zinc finger) in E3 ubiquitin-protein ligase SIAH1A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008974
Domain description: TRAF-like
Occurring in:
  1. E3 ubiquitin-protein ligase SIAH1A
IPR013010
Domain description: Zinc finger, SIAH-type
Occurring in:
  1. E3 ubiquitin-protein ligase SIAH1A
IPR018121
Domain description: Seven-in-absentia protein, TRAF-like domain
Occurring in:
  1. E3 ubiquitin-protein ligase SIAH1A
IPR013083
Domain description: Zinc finger, RING/FYVE/PHD-type
Occurring in:
  1. E3 ubiquitin-protein ligase SIAH1A
IPR004162
Domain description: E3 ubiquitin-protein ligase SINA-like, animal
Occurring in:
  1. E3 ubiquitin-protein ligase SIAH1A

Structure domains

CATH CATH domains
2.60.210.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Homology: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Occurring in:
  1. E3 ubiquitin-protein ligase SIAH1A
The deposited structure of PDB entry 2an6 contains 4 copies of CATH domain 2.60.210.10 (Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A) in E3 ubiquitin-protein ligase SIAH1A. Showing 1 copy in chain A.
3.30.40.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Herpes Virus-1
Homology: Zinc/RING finger domain, C3HC4 (zinc finger)
Occurring in:
  1. E3 ubiquitin-protein ligase SIAH1A
The deposited structure of PDB entry 2an6 contains 4 copies of CATH domain 3.30.40.10 (Herpes Virus-1) in E3 ubiquitin-protein ligase SIAH1A. Showing 1 copy in chain A.
SCOP SCOP annotation
69198
Class: All beta proteins
Fold: TRAF domain-like
Superfamily: TRAF domain-like
Occurring in:
  1. E3 ubiquitin-protein ligase SIAH1A
The deposited structure of PDB entry 2an6 contains 4 copies of SCOP domain 69198 (SIAH, seven in absentia homolog) in E3 ubiquitin-protein ligase SIAH1A. Showing 1 copy in chain A.

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