X-ray diffraction
2.48Å resolution


Source organism: Homo sapiens

Function and Biology Details

Reactions catalysed:
An alcohol + NADP(+) = an aldehyde + NADPH
L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + NADPH
Glycerol + NADP(+) = D-glyceraldehyde + NADPH
Allyl alcohol + NADP(+) = acrolein + NADPH
L-gulonate + NADP(+) = D-glucuronate + NADPH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Aldo-keto reductase family 1 member A1 Chain: A
Molecule details ›
Chain: A
Length: 324 amino acids
Theoretical weight: 36.49 KDa
Source organism: Homo sapiens
  • Canonical: P14550 (Residues: 2-325; Coverage: 100%)
Gene names: AKR1A1, ALDR1, ALR
Sequence domains: Aldo/keto reductase family
Structure domains: NADP-dependent oxidoreductase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 82.6Å b: 60Å c: 66.2Å
α: 90° β: 90° γ: 90°
R R work R free
0.19 0.19 not available