X-ray diffraction
1.92Å resolution

Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex

Source organism: Homo sapiens
Primary publication:
Fluoride inhibition of enolase: crystal structure and thermodynamics.
Biochemistry 45 793-800 (2006)
PMID: 16411755

Function and Biology Details

Reaction catalysed:
2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Gamma-enolase Chains: A, B
Molecule details ›
Chains: A, B
Length: 439 amino acids
Theoretical weight: 48.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P09104 (Residues: 2-434; Coverage: 100%)
Gene name: ENO2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21212
Unit cell:
a: 111.739Å b: 119.692Å c: 68.299Å
α: 90° β: 90° γ: 90°
R R work R free
0.234 0.211 0.249
Expression system: Escherichia coli