› 2ajv

X-ray diffraction
1.5Å resolution

Crystal Structure of Cocaine catalytic Antibody 7A1 Fab' in Complex with Cocaine

Released:
DOI: 10.2210/pdb2ajv/pdb
PDB 2ajv coloured by chain and viewed from the front.
PDB 2ajv coloured by chain and viewed from the side.
PDB 2ajv coloured by chain and viewed from the top.
Source organism: Mus musculus
Primary publication:
Complete reaction cycle of a cocaine catalytic antibody at atomic resolution.
Zhu X, Dickerson TJ, Rogers CJ, Kaufmann GF, Mee JM, McKenzie KM, Janda KD, Wilson IA
Structure 14 205-16 (2006)
PMID: 16472740

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Immunoglobulin kappa constant Chain: L
Molecule details ›
Chain: L
Length: 216 amino acids
Theoretical weight: 24.06 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01837 (Residues: 1-104; Coverage: 97%)
Gene name: Igkc
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chain: H
Molecule details ›
Chain: H
Length: 219 amino acids
Theoretical weight: 23.87 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: A2NUE8 (Residues: 19-117, 118-149; Coverage: 99%)
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand COC 1 x COC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: C2221
Unit cell:
a: 90.254Å b: 117.32Å c: 85.217Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.227

Quick links

Citations

1 review citation

Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicity.
Schindler et al. (2012)
17 other articles