PDBe 2aew

X-ray diffraction
2.7Å resolution

A model for growth hormone receptor activation based on subunit rotation within a receptor dimer


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Growth hormone-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 205 amino acids
Theoretical weight: 23.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P10912 (Residues: 47-251; Coverage: 33%)
Gene name: GHR
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-ID-B
Spacegroup: C2221
Unit cell:
a: 99.72Å b: 112.167Å c: 93.16Å
α: 90° β: 90° γ: 90°
R R work R free
0.262 0.257 0.302
Expression system: Escherichia coli