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Structure of a CED-4/CED-9 complex

Source organism: Caenorhabditis elegans
Biochemical function: caspase binding
Biological process: regulation of apoptotic process
Cellular component: perinuclear region of cytoplasm

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00931
Domain description: NB-ARC domain
Occurring in:
  1. Cell death protein 4
The deposited structure of PDB entry 2a5y contains 2 copies of Pfam domain PF00931 (NB-ARC domain) in Cell death protein 4. Showing 1 copy in chain B.

PF00619
Domain description: Caspase recruitment domain
Occurring in:
  1. Cell death protein 4
The deposited structure of PDB entry 2a5y contains 2 copies of Pfam domain PF00619 (Caspase recruitment domain) in Cell death protein 4. Showing 1 copy in chain B.

PF00452
Domain description: Apoptosis regulator proteins, Bcl-2 family
Occurring in:
  1. Apoptosis regulator ced-9
The deposited structure of PDB entry 2a5y contains 1 copy of Pfam domain PF00452 (Apoptosis regulator proteins, Bcl-2 family) in Apoptosis regulator ced-9. Showing 1 copy in chain A.

PF02180
Domain description: Bcl-2 homology region 4
Occurring in:
  1. Apoptosis regulator ced-9
The deposited structure of PDB entry 2a5y contains 1 copy of Pfam domain PF02180 (Bcl-2 homology region 4) in Apoptosis regulator ced-9. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001315
Domain description: CARD domain
Occurring in:
  1. Cell death protein 4
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Cell death protein 4
IPR011029
Domain description: Death-like domain superfamily
Occurring in:
  1. Cell death protein 4
IPR003093
Domain description: Apoptosis regulator, Bcl-2 protein, BH4
Occurring in:
  1. Apoptosis regulator ced-9
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. Cell death protein 4
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Cell death protein 4
IPR002182
Domain description: NB-ARC
Occurring in:
  1. Cell death protein 4
IPR026298
Domain description: Bcl-2 family
Occurring in:
  1. Apoptosis regulator ced-9
IPR036834
Domain description: Bcl-2-like superfamily
Occurring in:
  1. Apoptosis regulator ced-9
IPR046371
Domain description: Bcl-2, Bcl-2 homology region 1-3
Occurring in:
  1. Apoptosis regulator ced-9
IPR002475
Domain description: Bcl2-like
Occurring in:
  1. Apoptosis regulator ced-9

Structure domains

CATH CATH domains
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Cell death protein 4
The deposited structure of PDB entry 2a5y contains 2 copies of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Cell death protein 4. Showing 1 copy in chain B.
1.10.8.490
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helicase, Ruva Protein; domain 3
Homology: Ced-4 linker helical domain-like
Occurring in:
  1. Cell death protein 4
The deposited structure of PDB entry 2a5y contains 2 copies of CATH domain 1.10.8.490 (Helicase, Ruva Protein; domain 3) in Cell death protein 4. Showing 1 copy in chain B.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Cell death protein 4
The deposited structure of PDB entry 2a5y contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Cell death protein 4. Showing 1 copy in chain B.
1.10.533.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Death Domain, Fas
Homology: Death Domain, Fas
Occurring in:
  1. Cell death protein 4
The deposited structure of PDB entry 2a5y contains 1 copy of CATH domain 1.10.533.10 (Death Domain, Fas) in Cell death protein 4. Showing 1 copy in chain B.
1.10.437.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Apoptosis Regulator Bcl-x
Homology: Blc2-like
Occurring in:
  1. Apoptosis regulator ced-9
The deposited structure of PDB entry 2a5y contains 1 copy of CATH domain 1.10.437.10 (Apoptosis Regulator Bcl-x) in Apoptosis regulator ced-9. Showing 1 copy in chain A.
SCOP SCOP annotations
158326
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Occurring in:
  1. Cell death protein 4
The deposited structure of PDB entry 2a5y contains 1 copy of SCOP domain 158326 (CED-4 C-terminal domain-like) in Cell death protein 4. Showing 1 copy in chain B.
81269
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. Cell death protein 4
The deposited structure of PDB entry 2a5y contains 1 copy of SCOP domain 81269 (Extended AAA-ATPase domain) in Cell death protein 4. Showing 1 copy in chain B.
81313
Class: All alpha proteins
Fold: DEATH domain
Superfamily: DEATH domain
Occurring in:
  1. Cell death protein 4
The deposited structure of PDB entry 2a5y contains 1 copy of SCOP domain 81313 (Caspase recruitment domain, CARD) in Cell death protein 4. Showing 1 copy in chain B.
56855
Class: Membrane and cell surface proteins and peptides
Fold: Toxins' membrane translocation domains
Superfamily: Bcl-2 inhibitors of programmed cell death
Occurring in:
  1. Apoptosis regulator ced-9
The deposited structure of PDB entry 2a5y contains 1 copy of SCOP domain 56855 (Bcl-2 inhibitors of programmed cell death) in Apoptosis regulator ced-9. Showing 1 copy in chain A.

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