› 2a1l

X-ray diffraction
2.18Å resolution

Rat PITP-Beta Complexed to Phosphatidylcholine

Released:
DOI: 10.2210/pdb2a1l/pdb
PDB entry 2a1l coloured by chain, front view.
PDB entry 2a1l coloured by chain, side view.
PDB entry 2a1l coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms.
Vordtriede PB, Doan CN, Tremblay JM, Helmkamp GM, Yoder MD
Biochemistry 44 14760-71 (2005)
PMID: 16274224

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156879 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol transfer protein beta isoform Chain: A
Molecule details ›
Chain: A
Length: 270 amino acids
Theoretical weight: 31.36 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P53812 (Residues: 2-271; Coverage: 100%)
Gene name: Pitpnb
Sequence domains: Phosphatidylinositol transfer protein
Structure domains: Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4

Ligands and Environments

1 bound ligand:
Ligand PCW 1 x PCW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 65.945Å b: 65.948Å c: 133.513Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.257
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Lipid-transfer proteins in biosynthetic pathways.
D'Angelo et al. (2008)
10 more

5 mentions without citation

Lipid transfer proteins and instructive regulation of lipid kinase activities: Implications for inositol lipid signaling and disease.
Lete et al. (2020)
4 more