› 2a0c

X-ray diffraction
1.95Å resolution

Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor

Released:
DOI: 10.2210/pdb2a0c/pdb
PDB 2a0c coloured by chain and viewed from the front.
PDB 2a0c coloured by chain and viewed from the side.
PDB 2a0c coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor.
Krystof V, McNae IW, Walkinshaw MD, Fischer PM, Müller P, Vojtesek B, Orság M, Havlícek L, Strnad M
Cell. Mol. Life Sci. 62 1763-71 (2005)
PMID: 16003486

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: X
Molecule details ›
Chain: X
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CK9 1 x CK9
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P212121
Unit cell:
a: 53.242Å b: 70.945Å c: 71.869Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.191 0.244
Expression system: Not provided

Quick links

Citations

3 review citations

Cyclin-dependent kinase inhibitors closer to market launch?
Galons et al. (2013)
2 more

6 mentions without citation

Structural basis for the modulation of CDK-dependent/independent activity of cyclin D1.
Ferrer et al. (2006)
5 more