Structure analysis

Crystal Structure of Foxp2 bound Specifically to DNA.

X-ray diffraction
1.9Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero decamer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero decamer
Accessible surface area: 40600 Å2
Buried surface area: 20000 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): -2 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -221 kcal/mol
Symmetry number: 2

Macromolecules

Chains: F, G, H, I, J, K
Length: 93 amino acids
Theoretical weight: 11.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15409 (Residues: 502-594; Coverage: 13%)
Gene names: CAGH44, FOXP2, TNRC10
Pfam: Forkhead domain
InterPro:
CATH: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
SCOP: Forkhead DNA-binding domain

Search similar proteins

Name: 5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3'
Representative chains: A, C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 21 nucleotides
Theoretical weight: 6.39 KDa

Search similar DNA

Name: 5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3'
Representative chains: B, D
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 21 nucleotides
Theoretical weight: 6.49 KDa

Search similar DNA