2zu6

X-ray diffraction
2.8Å resolution

crystal structure of the eIF4A-PDCD4 complex

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of the eIF4A-PDCD4 complex.
Proc. Natl. Acad. Sci. U.S.A. 106 3148-53 (2009)
PMID: 19204291

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Eukaryotic initiation factor 4A-I Chains: A, C, D, F
Molecule details ›
Chains: A, C, D, F
Length: 388 amino acids
Theoretical weight: 44.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60842 (Residues: 20-406; Coverage: 95%)
Gene names: DDX2A, EIF4A, EIF4A1
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Programmed cell death protein 4 Chains: B, E
Molecule details ›
Chains: B, E
Length: 307 amino acids
Theoretical weight: 34.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q53EL6 (Residues: 163-469; Coverage: 66%)
Gene names: H731, PDCD4
Sequence domains: MA3 domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 156.893Å b: 165.384Å c: 100.424Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.248 0.294
Expression system: Escherichia coli