› 2zb5

X-ray diffraction
3Å resolution

Crystal structure of the measles virus hemagglutinin (complex-sugar-type)

Released:
DOI: 10.2210/pdb2zb5/pdb
PDB entry 2zb5 coloured by chain, front view.
PDB entry 2zb5 coloured by chain, side view.
PDB entry 2zb5 coloured by chain, top view.
Source organism: Measles virus strain Edmonston-B
Primary publication:
Crystal structure of measles virus hemagglutinin provides insight into effective vaccines.
Hashiguchi T, Kajikawa M, Maita N, Takeda M, Kuroki K, Sasaki K, Kohda D, Yanagi Y, Maenaka K
Proc Natl Acad Sci U S A 104 19535-40 (2007)
PMID: 18003910

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140105 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin glycoprotein Chain: A
Molecule details ›
Chain: A
Length: 481 amino acids
Theoretical weight: 53.42 KDa
Source organism: Measles virus strain Edmonston-B
Expression system: Homo sapiens
UniProt:
  • Canonical: P08362 (Residues: 149-617; Coverage: 76%)
Gene name: H
Sequence domains: Haemagglutinin-neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P41212
Unit cell:
a: 134.523Å b: 134.523Å c: 99.251Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.227 0.271
Expression system: Homo sapiens

Quick links

Citations

41 review citations

Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded.
Cattaneo et al. (2008)
40 more

17 mentions without citation

Receptor-mediated cell entry of paramyxoviruses: Mechanisms, and consequences for tropism and pathogenesis.
Navaratnarajah et al. (2020)
16 more