› 2z5x

X-ray diffraction
2.2Å resolution

Crystal Structure of Human Monoamine Oxidase A with Harmine

Released:
DOI: 10.2210/pdb2z5x/pdb
PDB entry 2z5x coloured by chain, front view.
PDB entry 2z5x coloured by chain, side view.
PDB entry 2z5x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors.
Son SY, Ma J, Kondou Y, Yoshimura M, Yamashita E, Tsukihara T
Proc Natl Acad Sci U S A 105 5739-44 (2008)
PMID: 18391214

Function and Biology Details

Reactions catalysed: 
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-149227 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amine oxidase [flavin-containing] A Chain: A
Molecule details ›
Chain: A
Length: 513 amino acids
Theoretical weight: 58.26 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P21397 (Residues: 12-524; Coverage: 97%)
Gene name: MAOA
Sequence domains: Flavin containing amine oxidoreductase
Structure domains:

Ligands and Environments


Cofactor: Ligand FAD 1 x FAD
3 bound ligands:
Ligand HRM 1 x HRM
Ligand DCX 2 x DCX
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: C222
Unit cell:
a: 135.263Å b: 218.706Å c: 54.373Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.255
Expression system: Saccharomyces cerevisiae

Quick links

Citations

30 review citations

Monoamine oxidases as sources of oxidants in the heart.
Kaludercic et al. (2014)
29 more

130 mentions without citation

Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine oxidases.
Edmondson et al. (2009)
129 more