Solution NMR

Solution structure of the chimera of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of hALK


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
ALK tyrosine kinase receptor; Fibroblast growth factor receptor substrate 3 Chain: A
Molecule details ›
Chain: A
Length: 153 amino acids
Theoretical weight: 16.95 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: O43559 (Residues: 8-120; Coverage: 23%)
  • Canonical: Q9UM73 (Residues: 1571-1589; Coverage: 1%)
Gene names: ALK, FRS3
Sequence domains: PTB domain (IRS-1 type)
Structure domains: PH-domain like

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: torsion angle dynamics
Chemical shifts: BMR11095  
Expression system: Not provided