PDBe 2yoh

X-ray diffraction
1.6Å resolution

Plasmodium falciparum thymidylate kinase in complex with a urea-alpha- deoxythymidine inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidylate kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 210 amino acids
Theoretical weight: 24.73 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8I4S1 (Residues: 1-210; Coverage: 100%)
Gene name: PF3D7_1251300
Sequence domains: Thymidylate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 49.26Å b: 58.43Å c: 71.83Å
α: 90° β: 96.11° γ: 90°
R-values:
R R work R free
0.165 0.162 0.219
Expression system: Escherichia coli BL21(DE3)