PDBe 2yof

X-ray diffraction
1.82Å resolution

Plasmodium falciparum thymidylate kinase in complex with a (thio)urea- beta-deoxythymidine inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidylate kinase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 210 amino acids
Theoretical weight: 24.73 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8I4S1 (Residues: 1-210; Coverage: 100%)
Gene name: PF3D7_1251300
Sequence domains: Thymidylate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P3121
Unit cell:
a: 109.639Å b: 109.639Å c: 121.892Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.189 0.231
Expression system: Escherichia coli BL21(DE3)