X-ray diffraction
2.25Å resolution

Crystal structure of human S-adenosylmethionine synthetase 2, beta subunit in Orthorhombic crystal form


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Methionine adenosyltransferase 2 subunit beta Chain: A
Molecule details ›
Chain: A
Length: 315 amino acids
Theoretical weight: 35.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q9NZL9 (Residues: 28-334; Coverage: 92%)
Gene names: MAT2B, MSTP045, Nbla02999, TGR, UNQ2435/PRO4995
Sequence domains: RmlD substrate binding domain
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2221
Unit cell:
a: 40.98Å b: 111.77Å c: 123.12Å
α: 90° β: 90° γ: 90°
R R work R free
0.177 0.175 0.218
Expression system: Escherichia coli BL21(DE3)