2y9q

X-ray diffraction
1.55Å resolution

Crystal structure of human ERK2 complexed with a MAPK docking peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 362 amino acids
Theoretical weight: 41.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P28482 (Residues: 1-360; Coverage: 100%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Sequence domains: Protein kinase domain
Structure domains:
MAP kinase-interacting serine/threonine-protein kinase 1 Chain: B
Molecule details ›
Chain: B
Length: 18 amino acids
Theoretical weight: 2.04 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9BUB5 (Residues: 434-451; Coverage: 4%)
Gene names: MKNK1, MNK1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 65.36Å b: 65.88Å c: 95.05Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.156 0.155 0.177
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided