2xl2

X-ray diffraction
2.4Å resolution

WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE RECRUITED TO NOVEL SITE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-158507 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 334 amino acids
Theoretical weight: 36.64 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P61965 (Residues: 1-334; Coverage: 100%)
Gene names: Big, Big3, Wdr5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Retinoblastoma-binding protein 5 Chains: C, D
Molecule details ›
Chains: C, D
Length: 14 amino acids
Theoretical weight: 1.54 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q8BX09 (Residues: 369-381; Coverage: 2%)
Gene name: Rbbp5

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 47.44Å b: 81.26Å c: 87.52Å
α: 90° β: 93.12° γ: 90°
R-values:
R R work R free
0.188 0.186 0.242
Expression systems:
  • Escherichia coli
  • Not provided