2xa0

X-ray diffraction
2.7Å resolution

Crystal structure of BCL-2 in complex with a BAX BH3 peptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Apoptosis regulator Bcl-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 207 amino acids
Theoretical weight: 22.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10415 (Residues: 1-207; Coverage: 87%)
Gene name: BCL2
Sequence domains:
Structure domains: Blc2-like
Apoptosis regulator BAX Chains: C, D
Molecule details ›
Chains: C, D
Length: 31 amino acids
Theoretical weight: 3.57 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q07813 (Residues: 52-82; Coverage: 16%)
Gene name: Bax

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P3121
Unit cell:
a: 81.973Å b: 81.973Å c: 138.85Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.222 0.242
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided