X-ray diffraction
1.9Å resolution

Crystal structure of human TBX5 in the DNA-free form


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
T-box transcription factor TBX5 Chain: A
Molecule details ›
Chain: A
Length: 203 amino acids
Theoretical weight: 23.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q99593 (Residues: 50-251; Coverage: 39%)
Gene name: TBX5
Sequence domains: T-box
Structure domains: Transcription factor, T-box

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 36.71Å b: 69.85Å c: 80.5Å
α: 90° β: 90° γ: 90°
R R work R free
0.213 0.21 0.264
Expression system: Escherichia coli BL21(DE3)