PDBe 2wwi

X-ray diffraction
2.99Å resolution

Function and Biology Details

Reaction catalysed:
ATP + dTMP = ADP + dTDP
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidylate kinase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 212 amino acids
Theoretical weight: 24.95 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8I4S1 (Residues: 1-210; Coverage: 100%)
Gene name: PF3D7_1251300
Sequence domains: Thymidylate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P3121
Unit cell:
a: 110.337Å b: 110.337Å c: 119.109Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.199 0.287
Expression system: Escherichia coli BL21(DE3)