PDBe 2vif

X-ray diffraction
1.45Å resolution

Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Suppressor of cytokine signaling 6 Chain: A
Molecule details ›
Chain: A
Length: 141 amino acids
Theoretical weight: 15.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O14544 (Residues: 361-499; Coverage: 26%)
Gene names: CIS4, SOCS4, SOCS6
Sequence domains: SH2 domain
Structure domains: SH2 domain
Mast/stem cell growth factor receptor Kit Chain: P
Molecule details ›
Chain: P
Length: 11 amino acids
Theoretical weight: 1.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P10721 (Residues: 564-574; Coverage: 1%)
Gene names: KIT, SCFR

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 30.377Å b: 60.143Å c: 71.367Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.142 0.139 0.198
Expression system: Escherichia coli BL21