X-ray diffraction
1.7Å resolution

Structural insights into the recognition of substrates and activators by the OSR1 kinase


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase OSR1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 96 amino acids
Theoretical weight: 10.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O95747 (Residues: 433-527; Coverage: 18%)
Gene names: KIAA1101, OSR1, OXSR1
Sequence domains: Oxidative-stress-responsive kinase 1 C-terminal domain
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Serine/threonine-protein kinase WNK4 Chains: C, D
Molecule details ›
Chains: C, D
Length: 6 amino acids
Theoretical weight: 708 Da
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q96J92 (Residues: 1015-1020; Coverage: 1%)
Gene names: PRKWNK4, WNK4

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 31.469Å b: 52.754Å c: 59.271Å
α: 90° β: 103.23° γ: 90°
R R work R free
0.2 0.198 0.239
Expression systems:
  • Escherichia coli
  • Not provided