› 2v24

X-ray diffraction
2.2Å resolution

Structure of the human SPRY domain-containing SOCS box protein SSB-4

Released:
DOI: 10.2210/pdb2v24/pdb
PDB 2v24 coloured by chain and viewed from the front.
PDB 2v24 coloured by chain and viewed from the side.
PDB 2v24 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
Filippakopoulos P, Low A, Sharpe TD, Uppenberg J, Yao S, Kuang Z, Savitsky P, Lewis RS, Nicholson SE, Norton RS, Bullock AN
OpenAccess logo J. Mol. Biol. 401 389-402 (2010)
PMID: 20561531

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SPRY domain-containing SOCS box protein 4 Chain: A
Molecule details ›
Chain: A
Length: 208 amino acids
Theoretical weight: 22.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96A44 (Residues: 28-233; Coverage: 76%)
Gene names: SPSB4, SSB4
Sequence domains: SPRY domain

Ligands and Environments

1 bound ligand:
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 104.22Å b: 104.22Å c: 40.78Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.209 0.26
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Applications of (19)F-NMR in Fragment-Based Drug Discovery.
Norton et al. (2016)
2 more

3 mentions without citation

Structural insight into HIV-1 capsid recognition by rhesus TRIM5α.
Yang et al. (2012)
2 more