PDBe 2uzy

X-ray diffraction
4Å resolution

Structure of the human receptor tyrosine kinase Met in complex with the Listeria monocytogenes invasion protein inlb: low resolution, Crystal form II

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Internalin B Chains: A, C
Molecule details ›
Chains: A, C
Length: 289 amino acids
Theoretical weight: 32.24 KDa
Source organism: Listeria monocytogenes EGD-e
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P25147 (Residues: 36-321; Coverage: 48%)
Gene names: inlB, lmo0434
Sequence domains:
Structure domains:
Hepatocyte growth factor receptor Chains: B, D
Molecule details ›
Chains: B, D
Length: 727 amino acids
Theoretical weight: 81.9 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08581 (Residues: 25-741; Coverage: 53%)
Gene name: MET
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 139Å b: 144.98Å c: 150.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.251 0.301
Expression systems:
  • Escherichia coli BL21(DE3)
  • Cricetulus griseus