2rod

Solution NMR

Solution Structure of MCL-1 Complexed with NoxaA

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 18.26 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P97287 (Residues: 152-308; Coverage: 47%)
Gene name: Mcl1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
Phorbol-12-myristate-13-acetate-induced protein 1 Chain: B
Molecule details ›
Chain: B
Length: 27 amino acids
Theoretical weight: 3.04 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9JM54 (Residues: 17-42; Coverage: 25%)
Gene names: Noxa, Pmaip1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli BL21(DE3)