X-ray diffraction
1.67Å resolution

Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain


Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only pentamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoblastoma-associated protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 347 amino acids
Theoretical weight: 40.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P06400 (Residues: 380-787; Coverage: 37%)
Gene name: RB1
Sequence domains: Retinoblastoma-associated protein B domain
Structure domains: Cyclin-like
Early E1A protein Chains: B, D, E
Molecule details ›
Chains: B, D, E
Length: 10 amino acids
Theoretical weight: 1.2 KDa
Source organism: Human adenovirus 5
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P03255 (Residues: 40-49; Coverage: 4%)

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P1
Unit cell:
a: 57.713Å b: 57.706Å c: 92.268Å
α: 94.34° β: 92.69° γ: 105.79°
R R work R free
0.198 0.195 0.218
Expression system: Escherichia coli BL21(DE3)