X-ray diffraction
2Å resolution

Methyltransferase domain of human suppressor of variegation 3-9 homolog 2


Function and Biology Details

Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(9) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(9)
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Histone-lysine N-methyltransferase SUV39H2 Chain: A
Molecule details ›
Chain: A
Length: 300 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9H5I1 (Residues: 112-410; Coverage: 73%)
Gene names: KMT1B, SUV39H2
Sequence domains:
Structure domains: SET domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 45.748Å b: 63.925Å c: 64.529Å
α: 90° β: 109.33° γ: 90°
R R work R free
0.179 0.177 0.213
Expression system: Escherichia coli