2qq0

X-ray diffraction
1.5Å resolution

Thymidine Kinase from Thermotoga Maritima in complex with thymidine + AppNHp

Released:

Function and Biology Details

Reaction catalysed:
ATP + thymidine = ADP + thymidine 5'-phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidine kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 184 amino acids
Theoretical weight: 20.68 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9WYN2 (Residues: 1-184; Coverage: 100%)
Gene names: TM_0401, tdk
Sequence domains: Thymidine kinase
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2
Unit cell:
a: 102.16Å b: 59.31Å c: 61.3Å
α: 90° β: 103.02° γ: 90°
R-values:
R R work R free
0.175 0.171 0.217
Expression system: Escherichia coli BL21