2qki

X-ray diffraction
2.4Å resolution

Human C3c in complex with the inhibitor compstatin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Complement C3 beta chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 643 amino acids
Theoretical weight: 71.27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 23-665; Coverage: 39%)
Gene names: C3, CPAMD1
Sequence domains:
Structure domains:
Complement C3c alpha' chain fragment 1 Chains: B, E
Molecule details ›
Chains: B, E
Length: 188 amino acids
Theoretical weight: 21.52 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 749-936; Coverage: 12%)
Gene names: C3, CPAMD1
Sequence domains: Alpha-2-macroglobulin family
Structure domains:
Complement C3c alpha' chain fragment 2 Chains: C, F
Molecule details ›
Chains: C, F
Length: 343 amino acids
Theoretical weight: 39.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 1321-1663; Coverage: 21%)
Gene names: C3, CPAMD1
Sequence domains:
Structure domains:
compstatin Chains: G, H
Molecule details ›
Chains: G, H
Length: 15 amino acids
Theoretical weight: 1.6 KDa

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 85.809Å b: 124.754Å c: 127.367Å
α: 90° β: 95.08° γ: 90°
R-values:
R R work R free
0.216 0.213 0.281