PDBe 2qe3

X-ray diffraction
2.5Å resolution

Crystal structure of human tl1a extracellular domain

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 15, secreted form Chain: A
Molecule details ›
Chain: A
Length: 184 amino acids
Theoretical weight: 20.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95150 (Residues: 72-251; Coverage: 72%)
Gene names: TL1, TNFSF15, VEGI
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P4132
Unit cell:
a: 120.404Å b: 120.404Å c: 120.404Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.209 0.263
Expression system: Escherichia coli