PDBe 2qdj

X-ray diffraction
2Å resolution

Crystal structure of the Retinoblastoma protein N-domain provides insight into tumor suppression, ligand interaction and holoprotein architecture

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoblastoma-associated protein Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 35.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06400 (Residues: 52-355; Coverage: 33%)
Gene name: RB1
Sequence domains: Domain of unknown function (DUF3452)
Structure domains:

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C222
Unit cell:
a: 72.296Å b: 106.649Å c: 98.191Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.228 0.276
Expression system: Escherichia coli