2qct

X-ray diffraction
2.8Å resolution

Structure of Lyp with inhibitor I-C11

Released:
Source organism: Homo sapiens
Entry authors: Yu X, Sun JP, Zhang ZY

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 22 Chains: A, B
Molecule details ›
Chains: A, B
Length: 313 amino acids
Theoretical weight: 36.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9Y2R2 (Residues: 1-294; Coverage: 36%)
Gene names: PTPN22, PTPN8
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 44.904Å b: 147.945Å c: 46.157Å
α: 90° β: 98.04° γ: 90°
R-values:
R R work R free
0.247 0.245 0.275
Expression system: Escherichia coli BL21