2qbw

X-ray diffraction
1.8Å resolution

The crystal structure of PDZ-Fibronectin fusion protein

Released:
Source organism: Homo sapiens
Primary publication:
Design of protein function leaps by directed domain interface evolution.
Proc. Natl. Acad. Sci. U.S.A. 105 6578-83 (2008)
PMID: 18445649

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Erbin Chain: A
Molecule details ›
Chain: A
Length: 195 amino acids
Theoretical weight: 20.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96RT1 (Residues: 1329-1412; Coverage: 6%)
Gene names: ERBB2IP, ERBIN, KIAA1225, LAP2
Structure domains:
Polypeptide Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 927 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: I212121
Unit cell:
a: 54.818Å b: 79.35Å c: 119.842Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.168 0.205
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided