2pvc

X-ray diffraction
3.69Å resolution

DNMT3L recognizes unmethylated histone H3 lysine 4

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA (cytosine-5)-methyltransferase 3-like Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 386 amino acids
Theoretical weight: 43.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UJW3 (Residues: 1-386; Coverage: 100%)
Gene name: DNMT3L
Sequence domains: Cysteine rich ADD domain in DNMT3
Structure domains: Vaccinia Virus protein VP39
Histone H3 peptide Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 7 amino acids
Theoretical weight: 777 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P6122
Unit cell:
a: 267.7Å b: 267.7Å c: 150Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.264 0.264 0.302
Expression systems:
  • Escherichia coli BL21
  • Not provided