X-ray diffraction
2.2Å resolution

The structure of Plasmodium falciparum spermidine synthase in complex with decarboxylated S-adenosylmethionine and the inhibitor cis-4-methylcyclohexylamine (4MCHA)


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
PABS domain-containing protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 321 amino acids
Theoretical weight: 36.64 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
  • Canonical: Q8II73 (Residues: 1-321; Coverage: 100%)
Gene name: PF3D7_1129000
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: C2
Unit cell:
a: 196.24Å b: 134.1Å c: 48.35Å
α: 90° β: 94.53° γ: 90°
R R work R free
0.2 0.196 0.239
Expression system: Escherichia coli