2pq8

X-ray diffraction
1.45Å resolution

MYST histone acetyltransferase 1

Released:
Source organism: Homo sapiens
Entry authors: Tempel W, Wu H, Dombrovski L, Loppnau P, Weigelt J, Sundstrom M, Arrowsmith CH, Edwards AM, Bochkarev A, Plotnikov AN, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT8 Chain: A
Molecule details ›
Chain: A
Length: 278 amino acids
Theoretical weight: 32.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H7Z6 (Residues: 174-449; Coverage: 60%)
Gene names: KAT8, MOF, MYST1, PP7073
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand COA 1 x COA
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 46.06Å b: 64.172Å c: 93.383Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.205 0.231
Expression system: Escherichia coli