› 2pku

Solution NMR

Solution structure of PICK1 PDZ in complex with the carboxyl tail peptide of GluR2

Released:
DOI: 10.2210/pdb2pku/pdb
PDB entry 2pku coloured by chain, ensemble of 20 models, front view.
PDB entry 2pku coloured by chain, ensemble of 20 models, side view.
PDB entry 2pku coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.
Pan L, Wu H, Shen C, Shi Y, Jin W, Xia J, Zhang M
EMBO J 26 4576-87 (2007)
PMID: 17914463

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163167 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PRKCA-binding protein Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 9.16 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9EP80 (Residues: 18-104; Coverage: 21%)
Gene names: Pick1, Prkcabp
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
peptide (GLU)(SER)(VAL)(LYS)(ILE) Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 576 Da
Source organism: Rattus norvegicus
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

18 review citations

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density.
Feng et al. (2009)
17 more

8 mentions without citation

Plasticity of PDZ domains in ligand recognition and signaling.
Ivarsson Y. (2012)
7 more