X-ray diffraction
2.11Å resolution

Crystal structure of the UHM domain of human SPF45 in complex with SF3b155-ULM5


Function and Biology Details

Structure analysis Details

Assemblies composition:
Non-polymer only dimer (preferred)
Non-polymer only tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Splicing factor 45 Chains: A, B
Molecule details ›
Chains: A, B
Length: 105 amino acids
Theoretical weight: 11.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q96I25 (Residues: 301-401; Coverage: 25%)
Gene names: RBM17, SPF45
Sequence domains: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Structure domains: Alpha-Beta Plaits
Splicing factor 3B subunit 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 10 amino acids
Theoretical weight: 1.31 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: O75533 (Residues: 333-342; Coverage: 1%)
Gene names: SAP155, SF3B1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 45.92Å b: 66.38Å c: 72.77Å
α: 90° β: 90° γ: 90°
R R work R free
0.211 0.208 0.273
Expression systems:
  • Escherichia coli
  • Not provided