PDBe 2p8u

X-ray diffraction
2Å resolution

Crystal structure of human 3-hydroxy-3-methylglutaryl CoA synthase I

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hydroxymethylglutaryl-CoA synthase, cytoplasmic Chains: A, B
Molecule details ›
Chains: A, B
Length: 478 amino acids
Theoretical weight: 53.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01581 (Residues: 16-470; Coverage: 88%)
Gene names: HMGCS, HMGCS1
Sequence domains: Hydroxymethylglutaryl-coenzyme A synthase C terminal
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments


Cofactor: Ligand COA 2 x COA
1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43212
Unit cell:
a: 92.762Å b: 92.762Å c: 235.532Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.159 0.202
Expression system: Escherichia coli