PDBe 2p6x

X-ray diffraction
1.9Å resolution

Crystal structure of human tyrosine phosphatase PTPN22


Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein phosphatase non-receptor type 22 Chains: A, B
Molecule details ›
Chains: A, B
Length: 309 amino acids
Theoretical weight: 36.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9Y2R2 (Residues: 1-302; Coverage: 37%)
Gene names: PTPN22, PTPN8
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 60.961Å b: 48.442Å c: 119.805Å
α: 90° β: 102.84° γ: 90°
R R work R free
0.166 0.164 0.217
Expression system: Escherichia coli