2p1l

X-ray diffraction
2.5Å resolution

Structure of the Bcl-XL:Beclin 1 complex

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
Non-polymer only dimer (preferred)
Non-polymer only hexadecamer
Non-polymer only tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-like protein 1 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 153 amino acids
Theoretical weight: 17.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07817 (Residues: 1-209; Coverage: 66%)
  • Best match: Q07817-2 (Residues: 1-125, 126-146)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:
Beclin-1-C 37 kDa Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 31 amino acids
Theoretical weight: 3.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14457 (Residues: 107-135; Coverage: 6%)
Gene names: BECN1, GT197

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21212
Unit cell:
a: 107.94Å b: 110.59Å c: 100.52Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.226 0.262
Expression system: Escherichia coli BL21(DE3)