2or9

X-ray diffraction
2.7Å resolution

The structure of the anti-c-myc antibody 9E10 Fab fragment/epitope peptide complex reveals a novel binding mode dominated by the heavy chain hypervariable loops

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
hetero dimer
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Monoclonal anti-c-myc antibody 9E10 Chains: L, M
Molecule details ›
Chains: L, M
Length: 218 amino acids
Theoretical weight: 24 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Monoclonal anti-c-myc antibody 9E10 Chains: H, I
Molecule details ›
Chains: H, I
Length: 228 amino acids
Theoretical weight: 24.9 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Myc proto-oncogene protein Chain: P
Molecule details ›
Chain: P
Length: 11 amino acids
Theoretical weight: 1.32 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01106 (Residues: 410-419; Coverage: 2%)
Gene names: BHLHE39, MYC

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P212121
Unit cell:
a: 76.068Å b: 111.88Å c: 134.119Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.252 0.31
Expression system: Not provided