X-ray diffraction
2Å resolution

Crystal Structure of the P38a-MAPKAP kinase 2 Heterodimer

Source organism: Homo sapiens
Primary publication:
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer.
J. Biol. Chem. 282 9733-9 (2007)
PMID: 17255097

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 14 Chains: A, D
Molecule details ›
Chains: A, D
Length: 366 amino acids
Theoretical weight: 42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q16539 (Residues: 2-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:
MAP kinase-activated protein kinase 2 Chains: C, F
Molecule details ›
Chains: C, F
Length: 24 amino acids
Theoretical weight: 2.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P49137 (Residues: 370-393; Coverage: 6%)
Gene name: MAPKAPK2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P31
Unit cell:
a: 81.55Å b: 81.55Å c: 121.36Å
α: 90° β: 90° γ: 120°
R R work R free
0.238 0.239 0.272
Expression systems:
  • Spodoptera frugiperda
  • Not provided