2odd

Solution NMR

Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor

Released:

Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor corepressor 2 Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 1.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9Y618 (Residues: 1101-1113; Coverage: 1%)
Gene names: CTG26, NCOR2
Protein CBFA2T1 Chain: A
Molecule details ›
Chain: A
Length: 64 amino acids
Theoretical weight: 7.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q06455 (Residues: 510-559; Coverage: 8%)
Gene names: AML1T1, CBFA2T1, CDR, ETO, MTG8, RUNX1T1, ZMYND2
Sequence domains: MYND finger
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Escherichia coli BL21