› 2odd

Solution NMR

Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor

Released:
DOI: 10.2210/pdb2odd/pdb
PDB 2odd coloured by chain and viewed from the front.
PDB 2odd coloured by chain and viewed from the side.
PDB 2odd coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.
Liu Y, Chen W, Gaudet J, Cheney MD, Roudaia L, Cierpicki T, Klet RC, Hartman K, Laue TM, Speck NA, Bushweller JH
Cancer Cell 11 483-97 (2007)
PMID: 17560331

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor corepressor 2 Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 1.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9Y618 (Residues: 1101-1113; Coverage: 1%)
Gene names: CTG26, NCOR2
Protein CBFA2T1 Chain: A
Molecule details ›
Chain: A
Length: 64 amino acids
Theoretical weight: 7.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q06455 (Residues: 510-559; Coverage: 8%)
Gene names: AML1T1, CBFA2T1, CDR, ETO, MTG8, RUNX1T1, ZMYND2
Sequence domains: MYND finger
Structure domains: Helix Hairpins

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

10 review citations

Histone methyltransferase SMYD2: ubiquitous regulator of disease.
Yi et al. (2019)
9 more

8 mentions without citation

Structure and function of SET and MYND domain-containing proteins.
Spellmon et al. (2015)
7 more