› 2nvh

X-ray diffraction
1.53Å resolution

Determination of Solvent Content in Cavities in Interleukin-1 Using Experimentally-Phased Electron Density

Released:
DOI: 10.2210/pdb2nvh/pdb
PDB entry 2nvh coloured by chain, front view.
PDB entry 2nvh coloured by chain, side view.
PDB entry 2nvh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Determination of solvent content in cavities in IL-1beta using experimentally phased electron density.
Quillin ML, Wingfield PT, Matthews BW
Proc Natl Acad Sci U S A 103 19749-53 (2006)
PMID: 17179045

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134409 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 beta Chain: A
Molecule details ›
Chain: A
Length: 153 amino acids
Theoretical weight: 17.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01584 (Residues: 117-269; Coverage: 57%)
Gene names: IL1B, IL1F2
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P43
Unit cell:
a: 54.506Å b: 54.506Å c: 75.359Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 not available not available
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Water in nonpolar confinement: from nanotubes to proteins and beyond.
Rasaiah et al. (2008)
2 more

19 mentions without citation

A review about nothing: are apolar cavities in proteins really empty?
Matthews et al. (2009)
18 more